Ginko Biloba

• Ginko leaf extracts advocated primarily for treatment of dementia, peripheral vascular disease, and neurosensory problems such as tinnitus.

• Effects have been attributed to platelet-activating factor antagonism of the ginkgolides and to the free radical scavenging and antioxidant properties of falvinoids in the herb.

• Two long term, randomized, placebo-controlled trials showed positive effects in patients with Alzheimer?s. Subjects took 40 mg tid and had significan but limited improvement at 52 weeks as compared to placebo.

• Meta-analysis shows mixed results for patients with intermittent claudication, and the positive effects were limited.

• Did not show to be more efficacious than placebo for tinnitus.